Histopathology

Histopathology

 

  
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Not many outside the medical profession know what histopathology is or what a histopathologist does. Yet, few surgical decisions - especially on cancer and related disorders would be possible without histopathology. Histopathology and cytopathology diagnose problems / diseases in tissues. This is far removed from the quantitative world of clinical chemistry and haematology. In this numberless world, it is the subtleties of the shades of grey that must be interpreted. Answering questions such as "Doctor do I have cancer?", and "Will my disease respond to treatment?", fall under the purview of a histopathologist's responsibilities. Here is where science meets the art of medicine and may even have to bow to it. The skill of the histopathologist is not easily acquired. It is honed and tempered by long years in the field. Histopathologists are therefore the rara avis of the pathology world.

Our Team

The SRL Diagnostics Private Limited group (Formerly Piramal Diagnostic Services Pvt. Ltd.)  in its mission for excellence in pathology, recognized the need for good histopathology and cytopathology services. Towards this goal it has established a modern histopathology laboratory fully equipped to provide high quality histopathology and cytopathology services. These services will answer diagnostic and therapeutic questions in surgical pathology in a timely and comprehensive manner. The laboratory is accredited by  NABL.

The centre is headed by Dr. Anita M. Borges, M.D. FRC Path, a surgical pathologist of repute who has spent 25 years as a cancer pathologist in the UK, USA and in India. She is ably supported by Dr.Jay Mehta, M.D., trained at Tata Memorial Hospital Mumbai and Dr. Vinita Pant MD.

Tests Available

The centre offers routine histopathology and cytopathology services, including Fine needle aspiration cytology (FNAC) and screening tests for cancer. Immunohistochemistry for all routine diagnostic and predictive markers is currently available. Additionally, the centre offers esoteric tests at the cutting edge of technology and expertise, such as molecular genetic markers of diagnostic and therapeutic value.

The SRL Diagnostics’ Histopathology Centre is truly committed to excellence. This is its raison d etre and its promise.

Immunohistochemistry

We test for the following Anti-bodies at the SRL Diagnostics Center of Excellence - Histopathology
 

Epithelial markers: Mesenchymal markers:
  • CK (AE1/ AE3)
  • LMW - CK (CK 8/18)
  • EMA
  • CEA
  • HMW-CK (34 Beta E12)
  • Vimentin
  • SMA
  • Desmin
  • Calponin Myogenin
  • GFAP
Mesothelioma markers:Vascular markers:
  • Calretinin
  • HBME-1
  • CK5/6
  • WT-1
  • CD 31
  • CD 34
  • Factor VIII
Germ cell markers:Neuroendocrine markers:
  • PLAP
  • α-fetoprotein
  • C-kit
  • hhCG
  • PgP 9.5
  • Synaptophysin
  • Chromogranin
  • S-100 protein
Hormone receptors:Miscellaneous:
  • ER
  • PR
  • c erb B2
  • CMV
  • HMB-45
  • HPV
Lymphoma markers:
  • CD 45
  • CD 20
  • CD 3
  • CD 5

 

  • CD 10
  • CD 43
  • CD 30
  • CD 15
  • alk-1
  • TdT
  • Mic-2
  • CD 21
  • IgG
  • IgM
  • MUM 1
  • Oct -2
  • TRAP
  • Annexin A1
  • CD 23
  • CD 68
  • CD 56
  • bcl-2
  • bcl-6
  • HHV-8
  • Hairy cell leukemia Antigen (DBA 44)
  • kappa
  • lambda
  • CD 138
  • Cyclin D1
  • Ki-67 / MIB-1
  • MPO
  •   CD2
  • CD4
  • CD7
  • CD8
  • CD57
  • CD99
  • Granzyme B
Markers to detect metastasis of unknown origin:
  • CK 7
  • CK 20
  • PSA
  • Ca-125 
  • TTF-1
  • Thyroglobulin 
  • Calcitonin
  • Inhibin
  • Napsin A
  • Hepatocyte specific antigen
  • HBME-1
  • Pax -8
  • CD10
Molecular Oncology
Lymphoma  -    B & T Cell antigen receptor gene rearrangement studies
Soft Tissue Sarcomas -     PNET, Synovial Sarcoma, DSRCT

Solid Tumors – K RAS / EGFR/ BRAF -  Mutation Analysis

EGFR Article

- Participant Summary

- Report Card